Abstract

Urine samples of human's mid-stream urinary tract were collectedfrom patients (males and females)who suffered from signs of urinary tractproblems . These specified bacteria were isolated and classified according tospecies .Bacteriological results indicated the existence of P.mirabilis, which wasthe most familiar kind to cause these infections compared to other bacteria .A dose of 9.0 × 109 alive P.mirabilis bacterial cells was injected afterbeing killed on bases of a limited period of time intraperitonially in eachlaboratory rat ,signs of infections were noticed and later extrahistoimmunopathological changes were studied in accordance with their sicknessstages.Results Showed the followings:Bacterial infections were persistent and their severity was varied betweenacute and chronic infections for all the period of the experiment .Theseconditions were positive for all the urinary tract components, urethras ,urinarybladder and urethra.The strength of histoimmunopathological changes was varied among ratsof the same group for all the period of the experiment ,but in general thesechanges varied from simple to moderate specially in the first week of inoculation.However ,animals did have symptoms such as hyperemia and edema whileothers suffered from necrosis , staffing of medulla , hyaline casts andinflammatory edema .Inflammation severity was increased after the first week and animalssuffered from a wide destruction in their kidney tissue because of inflammableedema which experienced neutrophils penetration in the kidney tissues and thecollective tubules ; as a result, R.B.C `s were presented in their urine . Moreover,in the second week their inflammatory conditions were variably extended tochronic inflammation in the bladder through the urethras and then to urethra .Also, swelling of the mucous membrane of the bladder and urethra. Rats mayhave inflammable edema and chancre with severe edema in the inflamed cells

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