Evaluation of serum adenosine deaminase activity in acute lymphoid leukemia in Erbil city

Abstract

Background and objectives: Adenosine deaminase (ADA), is an enzyme that catalyzes hydrolytic deamination of either adenosine or deoxy adenosine to produce inosine and deoxy inosine respectively. The aim of the present study is to evaluate the serum ADA activity in acute lymphoid leukemia.Method: A prospective study was carried out from January to June 2011 by the clinical biochemistry department in College of Medicine-Hawler Medical University on (30) patients with Acute lymphoid leukemia (group 1), and (30) healthy individuals, (group 2).Results: The mean value of serum ADA activity was significantly lower in Acute lymphoid leukemia (group 1), than those of healthy individuals, (group 2) (p<0.01), and both ions Na+ and K+ acted as an activators for Serum ADA activity.Conclusion: Based on the findings, it can be concluded that in acute lymphoid leukemia the activity of Serum ADA was decreased due to decline in the immunity.