Effect of Vitamin D Deficiency on Pulmonary Function Test in a Normal Population

Abstract

Background: During the past years, the role of Vitamin D on wide biologic processes has received the attractiveness. Moreover, the role ofVitamin D in the prevention and treatment of respiratory infections has already been confirmed. Objective: In the present study, the pulmonaryfunctions, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) ratio, and FEV1/FVC ratio were compared betweenhealthy individuals with and without Vitamin D deficiency. Materials and Methods: In the current case–control study, the pulmonary functionsof healthy individuals with normal Vitamin D (control = 51) and with Vitamin D deficiency (cases = 57) were compared through statisticalanalysis. The individuals recruited in the study were screened from the outpatient clinic of medicine department of a public hospital purposively.The Vitamin D level <50 nmol/L was considered deficient. The reference values of pulmonary functions were considered as follows: FVCbetween 80% and 120% as normal and <80% as reduced; FEV1 ≥75 as normal and <75 as reduced; FEV1/FVC between 80% and 120%as normal. Results: The present study showed that individuals with normal level of Vitamin D (control) and those with deficient level ofVitamin D (case) were comparable in age (39.09 vs. 41.33 years; P = 0.393), and body mass index (27.48 vs. 28.39; P = 0.475), respectively.In addition, both case and control groups were similar in FVC (93.98 vs. 93.12; P = 0.653), FEV1 (90.88 vs. 89.39L; P = 0.752), and FEV1/FVC (95.94 vs. 95.01%; P = 0.777) respectively. Conclusion: The study did not show a significant difference in baseline characteristics andof those spirometry functions (FVC, FEV1, and FEV1/FVC) between the healthy individuals with normal and deficient Vitamin D levels.