INTRAUTERINE INSEMINATION TREATMENT IN SUB FERTILITY: ANALYSIS OF FACTORS AFFECTING OUTCOME

Abstract

Background Intra uterine insemination is an assisted reproductive technique using husbandor donor sperm, at the time of ovulation in natural or stimulated cycle put in the uterine cavityor in the cervical canal.Objective To identify factors that can predict successful outcome in intrauterineinsemination.Methods a prospective study, 193 cycles of intrauterine insemination were analyzed toidentify prognostic factors regarding treatment outcome. The variables selected for analysiswere: female age, infertility duration and etiology, types of infertility, sperm parameters afterpreparation (count and progressive motility), number of preovulatory follicles, thickness ofendometrium and type of ovarian stimulation. The data were analyzed with chi square test.Results The overall pregnancy rate was 7.8%; the miscarriage rate was 60%, and no ectopicpregnancy or multiple pregnancies were encountered. Five significant variables wereidentified for successful outcome: endometrial thickness (P=0.001), number of treatmentcycles (P=0.002), number of preovulatory follicles (P=0.038), progressive motility of spermafter preparation (P=0.05), and female age (P=0.05).Conclusion intrauterine insemination should be considered prior to more invasive andexpensive other assisted reproductive techniques as in vitro fertilization and gamete intraFallopian transfer. Careful couple's selection is a crucial factor in enhancing conception withthis method.

Keywords

IUI, Infertility, ART