Formulation and Evaluation of Floating Microspheres of Clarithromycin


AbstractIn this work we prepare, characterize and evaluatefloating microspheres of Clarithromycinby ionicgelation method with an aim of increasing the gastric residence time and for controlledrelease.Gelatin, polymeric mixture of gelatin and Hydroxy ethyl cellulose (HEC) were used aspolymers. Sodium bicarbonate was used as the gas-forming agent. The production microsphereswere characterized by Fourier transform infrared spectroscopy (FT-IR), differential scanningcalorimetry (DSC), and photomicrographs microscopy. The prepared floating microspheresevaluated by particles size distribution, floating behavior, drug content, entrapment efficency,morphology and in vitro release werestudied.The micros pheres diameters range322.49μm-584.64μm.The results the release rate decrease with increaseing coeting material concentration. Thefloating microspheres followed zero order kinetics and drug mechanisam releasedtoPeppas model.The microspheres exponential coefficient values between 0.559 and 0.911 that indicatied to nonfickian diffusion controlled release mechanism.