THE PROFILE OF NEONATAL SEPSIS IN DUHOK CITY AND PREDICTORS OF MORTALITY: A PROSPECTIVE CASE SERIES STUDY

Abstract

ABSTRACTBackground: Neonatal sepsis is a major cause of death all over the world. Risk factorsrepresent an interaction between maternalimmunity and the defense mechanisms of the neonate.epidemiological, clinical and laboratory profiles of neonates with sepsis in relation tooutcome and to determine the predictors of outcome.Subject and Methods: A prospective study included neonates with sepsis admitted toneonatal care unit. 126 neonates with features of sepsis were included with age ranged from(1-30) days. From each patient, neonatal and maternal data were collected and clinicalfeatures as well as laboratory test results of hemoglobin, platelets count. total white blood celland absolute neutrophil count , Cstatistically analyzed.Results: of 126 neonates, 32 (25.39%) died while others survived. Age < 7 days was in61.9% of all cases, 69.84% had respiratory distress syndrencephalopathy, 60.31% were preterm, 61.9% were born vaginally and male to female ratiowas 1.73:1. There is a significant relation of mortality to respiratory distress syndrome andhypoxic ischemic encephalopathy, preterm dVomiting, apnea, sclerema, cyanosis and tachypnea were significantly related to themortality. Eschericia coli weremortality is with Acenatobacterbaumanirelation. The C reactive protein was>10 mg/dl was in higher number of neonates with sepsiswho died by comparison to those who survived, with a significant relation.Conclusions: Neonatal sepsis is still a cthe pattern of causative organisms and this requires more monitoring and periodicsurveillance. There is a real need to find out the local antibiotic sensitivities of patestablish an optimal empirical treatment before the results of culture and sensitivity areavailable.