Serum Protein Levels and Albumin/Globulin Ratio in Patients with Uterus, Ovary, and Breast Tumors Compared to Healthy Women in Kirkuk City

Abstract

Background: Gynecological cancer is one of the most serious public health problems in the world with main gynecological cancers, uterus,breast, and ovarian, causing morbidity with severe suffering and a high mortality. Objective: This study aimed to investigate the levels of thetotal protein (TP), albumin (Alb), globulin (Glo), and Alb/Glo ratio in the female patients with (uterus, ovary, and breast) cancer comparedto healthy females. Materials and Methods: This study included 120 females with (28 uteri, 31 ovaries, and 25 breasts) cancer patientsand 36 healthy control participants, with age ranges between (20 and 42) years. Results: Alb levels significantly (P ≤ 0.05) decreased in allpatient samples except those with uterus cancer who showed significant increase (P ≤ 0.05) compared to healthy participants, and Glo levelssignificantly (P ≤ 0.05) decreased for uterus and breast cancer samples and nonsignificant (P ≤ 0.05) decrease in patients with ovary cancercompared to healthy participants; finally, the ratio of Alb./Glo. showed significant (P ≤ 0.05) decrease in all patients group except patientswith breast cancer showed significant increase (P ≤ 0.05) compared to healthy participants. The results of correlation coefficient indicated thatthere were significant (P ≤ 0.05) positive correlations between TP and Glo for uterus and breast cancer patients and between TP and Alb forovary cancer patients. Conclusion: The ratio of Alb/Glo was significantly (P ≤ 0.05) decreased in all patients group except patients with breastcancer who showed significant increase (P ≤ 0.05) compared to healthy participants which could be used in the diagnosis of these patients.