The Role of Anticardiolipin and Antiphospholipid Antibodies in Pregnants with Chronic Periodontitis

Abstract

The aim of the study is to measure immunological and biochemical changes in blood and saliva of pregnant women with history of abortion and having chronic periodontitis. Materials and Methods: The study group consisted of (50) pregnant women at different stages of pregnancy with ages between (17-40) years old with history of one or more consecutive unexplained abortion and having chronic periodontitis, while the control group consisted of (10) pregnant women of comparable age to the study group with no history of any abortion with healthy periodontal conditions. Oral examination and the following parameters were studied: plaque index (PI), periodontal pocket depth index (PPD), bleeding on probing index (BOP), and anticardiolipin value (IgG), antiphospholipid value (IgG), highly sensitivity CRP concentration, and peroxidase enzyme activity were evaluated. Results: The serological and biochemical changes showed that highly levels of ACLA (IgG) and APLA (IgG) in the study group compared to control group. hs- CRP concentration in study and control group was same, peroxidase enzyme activity was elevated in the study group compared to the control group. There was a positive correlation between serum ACLA, peroxidase enzyme activity and periodontal parameters, and also a positive correlation between hs-CRP and PI, while reverse correlation between hs-CRP and PPD and BOP. Conclusion: Detection of high level of anticardiolipin and antiphospholipid in the serum of study group with significant difference compared with control group. High level of hs-CRP found in both study and control group without significant difference. Detection of significantly high level of peroxidase enzyme activity with the study group compared to control group