Increased risk of congenital hypothyroidism due to prolonged use of synthetic progesterone during pregnancy


Until the 10th week of pregnancy, the corpus luteum produce the most of progesterone hormone. Zinc and potassium allow the thyroid hormone to enter the cell and then to be converted to the active form known as T3. Estrogen can cause copper retention if zinc or progesterone levels are too low. The aim of this study is to estimate the effect of synthetic progesterone taken during pregnancy on the increasing risk of congenital hypothyroidism in newborn. A case control study comparing neonates born to mothers whom received synthetic progesterone during pregnancy to neonates of mothers with no history of receiving synthetic progesterone. Neonates with abnormal thyroid function test were recorded. The serum values of T4, T3, TSH were done for all included mothers to exclude any thyroid disease. Mothers with suspected thyroid disorders, use of antiseptics, drugs, or any agents containing iodine were not included. Preterm neonates and those with suspected thyroid agenesis (by thyroid ultrasonography) were also not included. Women received synthetic progesterone had neonates with abnormal thyroid function test. This is significantly associated with the timing and duration of synthetic progesterone use in gestational period. In conclusion; the use of synthetic Progesterone during gestational period is associated with increased risk of congenital hypothyroidism.