Preparation of Drugs Carrier Vitamin B2 and Studying their Controlled Drug Release


This study describes modification of Vitamin B2 as drug derivatives, which were prepared through esterification of some –OH groups of vitamin B2 with Amoxillinyl or Ibuprofenyl or Cephalexineoyl or Mefenamyl acid chlorides, with different modified ratios. This new idea was applied to improve the prolong delivery of vitamin B2 with controlling release of bonded antibiotics. The new prepared drug vitamin derivatives were characterized by FT-IR and UV. spectra, and the physical properties were studied; the controlled drug release was studied with different pH values at 37oC, many advantages have been obtained from this new preparation of scientific and therapeutic uses.