Role of Periostin in Iraqi Asthmatic Patients

Abstract

Background: Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation. The understanding of the pathogenesisof the disease is essential to improve the plan of management. Objective: The objective of this study is to identify the role of periostin asinflammatory biomarker of asthma. Materials and Methods: A total of 200 participants were enrolled in the study, of which there are100 controls and 100 asthmatic patients. Blood samples were obtained from the participants for periostin investigations by enzyme‑linkedimmunosorbent assay assay. Results: Serum periostin concentrations were significantly (P < 0.001) higher in asthmatic patients (mean ± standarddeviation [SD]; 68.152±9.792) compared to control group (mean ± SD; 46.488 ± 4.237). Periostin correlated negatively with forced expiratoryvolume (FEV) 1% and FEV1/forced vital capacity (FVC) in asthmatic patients. Conclusions: Serum periostin is increased in Iraqi asthmaticpatients compared to controls and periostin correlated negatively with FEV1% and FEV1/FVC in asthmatic patients. Asthma is the mostsignificant variable relates to high periostin serum concentration.