The Assessment of Some Serum Biomarkers of Fibromyalgia Syndrome in Pre and Postmenopausal Women in Relation to Obesity


The objective of this study is to evaluate the level of parathyroid hormone (PTH), Co enzyme Q (Co Q) and total antioxidant status (TAS) in serum’s women with fibromyalgia syndrome firstly, then to assess the influence of age and obesity on these biomarkers. This study was performed at Rheumatology and Rehabilitation Consultation Unit in Baghdad Teaching Hospital. Blood sampling from (59) women with fibromyalgia syndrome (FMS) and (30) control be taken. The mean age of FMS group was (42.22±15.34) years and for control was (40.7±18.22 years) and body mass index (BMI) for patients and control were (31.83 ± 5.05 and 30.09± 4.87) correspondingly. Those participants were subdivided into four different groups according to menopausal status; FMS before menopause were (30.14±10.58 and for control were 29.74± 12.21) years, post menopause FMS age were (53.2 ± 16.18 and control were 47.8 ±12.51) years and BMI to measure serum (PTH and Co Q) by enzyme linked immune sorbent assay (ELISA) and (TAS) by spectrophotometry. Results analyzed by SPSS version 24, independent samples T-test and Pearson’s correlation, P values < 0.05 were considered significant. The results record increment of serum’s PTH levels significantly, decrement of Co Q (P value<0.05) and non- significant decreased TAS (P value> 0.05) in FMS comparing with control group. Considering the age; PTH serum level showed insignificant increase and decrease of (Co Q and TAS) (P value >0.05 and P value< 0.05) respectively in post menopause comparing with pre menopause. According to BMI; serum PTH level record a significant raise in obese group (P value <0.003), reduction of serum Co Q significantly (P value< 0.05) and insignificantly for TAS (P value> 0.05). The mean serum level of PTH before menopause correlate significantly with TAS (P value= 0.034) also with Co Q of both FMS and control groups when BMI>30 (P value= 0.029 and P value= 0.043) respectively. In post menopause of both (FMS and control) PTH correlate positively (P value=0.05). Independent T- test for pre and post menopause FMS showed significance variance in TAS only (P value=0.004). Independent T- test for obese and non- obese FMS showed significant variance in PTH and TAS (P value=0.032 and P value= 0.0001). In conclusion the obesity and menopause play an imperative role in the etiology of FMS relative with serum’s biomarkers (PTH, Co Q and TAS).