Evaluation of Salivary Oxidative Stress Marker (Lipid Peroxidation), and Non-Enzymatic Antioxidants (Vitamin C and Vitamin E) in Patients with Acute Myocardial Infarction

Abstract

Acute Myocardial Infarction (AMI), is the major cause of mortality and morbidity. There is substantial evidence that oxidative stress plays the major role in the atherosclerotic process. This study was aimed to evaluate the levels of salivary malondialdehyde (MDA), total antioxidant capacity (TAC) and non-enzymatic antioxidants (Vitamin C and Vitamin E) in AMI patients. Materials and methods: Sixty AMI patients (35 Males and 25 Females) with mean age of 54 ± 6.7 years and sixty control subjects with mean age 55 ± 6.2 years were incorporated in this study. Un stimulated saliva were collected from each subject in both groups. Malondialdehyde, and Total Antioxidant Capacity, Vitamin C and Vitamin E levels in saliva were estimated spectrophotometrically. SPSS computer software was used for data analysis. Results: Salivary MDA and TAC was significantly elevated in AMI patients compared with controls, while Vitamin C and Vitamin E were significantly decreased in AMI patients. Conclusions: Oxidative stress was increased in saliva of AMI patients, raised saliva MDA and TAC serve as marker of detecting chronic inflammation or be elevated as a consequence of oxidative stress in AMI patients. It may be taken in consideration that the saliva is so important tool in evaluation of lipid peroxidation and antioxidant agents to confirm the diagnosis of certain diseases.