Evaluation of Serum Malondialdehyde, Glutathione peroxidase, Superoxide dismutase, and Catalase levels in Hormonal Contraceptives in Tikrit City

Abstract

ABSTRACT: Background: Oxidative stress is associated with the development of several disorders including cardiovascular disease and cancer. Among conditions known to influence oxidative stress, the use of oral contraception (OC) in women has been a matter of ongoing discussion. The aim of the study report to evaluate the impact of oral contraceptive formulation containing 30 mg oestrogen (ethyloestradiol) and 1 mg progestin (norethisterone acetate) on lipid peroxidation, GPx, SOD, and catalase levels. Patients & Methods: The present study was conducted in Family planning in Salahalddin Teaching Hospital in Tikrit province during the period from Feb 2016 until March 2017, Serum glutathione peroxidase (GPx) and , malondialdehyde (MDA), Super oxide dismutase (SOD), and catalase levels were estimated in 50 women who were using oral contraceptives for at least 1 year. Fifty- contraceptive users participated in the study as a control group. They were drawn from the same population and matched for age with the contraceptive-users group. Results: The serum level of MDA, and GPx was significantly higher in women were using oral contraceptive than control group(11.872 ± 1.13 μM vs. 9.148 ± 1.179 μM respectively, 45.140 U/g Hb ±2.265 vs. 29.86 U/g Hb ±2.31 ) respectively . On the other hand the serum SOD, catalase values in women using oral contraceptives were significantly lower than control group.( 2.72 U/L ± 0.479 vs. 3.5599 U/L ± 0.496 , 22.452 K/ml ± 2.045 vs. 26.370 K/ml ± 1.523 ) respectively. Conclusion: Oral contraceptive pills showed a significant decreasing effect on the antioxidant status of its users .Routine monitoring of the antioxidant status of women on oral contraceptive is recommended.