Characteristic Abnormalities in Serum Biochemistry during Congestive heart failure

Abstract

ABSTRACT: Background: Congestive heart failure (CHF) is a complex clinical syndrome characterized by dyspnea, fatigue, and signs of volume overload, which may include peripheral edema and pulmonary rules. Aim: The goal of the current study was to evaluate the alterations in different biochemical parameters including leptin, Adiponectin, ghrelin, Ceruloplasmin , concentration in patients with congestive heart failure. Patients and Methods: The total of 60 patients (19 Males and 11 Females) were enrolled in this study, 30 of them with congestive heart failure (study group) and 30 with apparently healthy subjects (13Males and 17 Females) ( control group). Results: The levels of leptin, ceruloplasmin, copper, and sialic acid , TNF-α, and CRP were significantly elevated in patients group, while adiponectin , ghrelin, Vitamin C and E were significantly lower in patients group compared to control group, there was positive correlation between leptin with adiponectin and ghrelin , adiponectin with ghrelin, Vitamin C with E ,ceruloplasmin with copper in congestive heart failure patients. Conclusions: Serum leptin, ghrelin and adiponectin are biomarkers for and correlated to CHF not only in the role they might play in the pathogenesis of the disease but also in their severity. Serum ceruloplasmin, copper, and sialic acid, levels, may serve as prognostic indicators in patients with CHF.