Evaluation of lipid profile for psoriatic patients treated by cyclosporine and biological treatment

Abstract

Background: Psoriasis is a common disease with the population prevalence ranging from 2% to 3%. Its prevalence in the population is affected by genetic, environmental, Psoriasis is associated with an atherogenic lipid profile but longitudinal changes in lipids around disease onset are unknown. Because of the wide range of comorbid conditions associated with psoriasis, comprehensive screening and treatment must be implemented to most effectively manage psoriasis patients.The purpose of our study is to examine the effect of type of treatment on serum lipid profiles for psoriatic patients .Methods We compared changes in lipid profiles in a psoriatic patient never treated incident 20 patients with 5psoriatic patient treated by cyclosporine and 5 psoriatic patient treated by biological treatment (infliximab) all lipid measures index date were abstracted. Random-effects models adjusting for age, sex and calendar year were used to examine trends in lipid profiles.Result : decrease LDL and increase HDL level with biological treatment, but no effect of cyclosporine on lipid profile.Conclusions: This study results showed a good effect of biological treatment on lipid profile.