Study of Growth Differentiation Factor 15(GDF15) and Some Biochemical Parameters in Multiple Myeloma Patients Subjected to Chemotherapy with Added Paroxetine in-Vitro


Introduction: Multiple myeloma (MM) is a cancer that shapes fromexcessive amounts of a monoclonal immunoglobulin (Ig) which accumulate in the bone marrow, where they assemble healthy blood cells. Materials and Methods: there are two lines was dealt with it: For in vivo the study involved 80 multiple myeloma Patients grouped according sessions of chemotherapy (new diagnosis without treatment, and patients subjected to six sessions of chemotherapy treatment) for each group the following biochemical parameters were measured Growth differentiation factor 15 (GDF-15), albumin, calcium, C reactive protein(CRP) in serum. In vitro was measured Growth differentiation factor 15 on RPMI 8226 cell line of multiple myeloma with mixture of chemotherapy (Mix1) and with combination of standard chemotherapy and antideportation paroxetine(Mix2).Results: In serum Growth differentiation factor 15 was showed significantly increased (p<0.05) for 1st cycle and 6th Cycle in comparison with new diagnosis group, for other cycles there are no significant difference. For Serum albumin, calcium and, C-reactive protein were appeared no significant between-groups differences when compared with their new diagnosis patients’ group. In vitro Growth differentiation factor 15 was appeared significant different when compared results of cell line with Mix1 in comparison to Mix2.