Association of Serum Ferritin with Metabolic Syndrome in Type II Diabetes from Medical City Hospital in Iraq


ABSTRACT:BACKGROUND:Metabolic syndrome is a constellation of risk factors of metabolic origin that are accompanied byincreased risk of cardiovascular disease and type II diabetes. These risk factors are atherogenicdyslipidemia, elevated blood pressure, elevated plasma glucose, a prothrombotic state, and aproinflammatory state. The two major underlying the risk factors of metabolic syndrome are obesityand insulin resistance; exacerbating factors are physical inactivity, advancing age, and endocrine andgenetics . The condition is progressive, beginning with borderline risk factors that eventuallyprogress to categorical risk factors. In many patients, metabolic syndrome culminates in type IIdiabetes, which further increases risk for cardiovascular disease. Hyperferritinemia has been linkedwith a wide spectrum of pathologies, including diabetes, cardiovascular disease, neurodegenerativedisorders, and metabolic syndrome.OBJECTIVE:The association between serum ferritin and metabolic syndrome components (hypertension,dyslipidemia, body mass index) in cohort of Iraqi patients diagnosed with type II diabetes mellitus.PATIENTS AND METHODS:This a case-control study that was conducted at the teaching laboratories of the Medical Cityhospital . The study included 60 patients with type II diabetes mellitus and 25 healthy controlsmatching in age and gender . Height , body weight, waist circumference along with systolic anddiastolic blood pressures were measured .The obtained serum samples were used to measure: serumferritin, total cholesterol, HDL-cholesterol, LDL-cholesterol , TG, fasting serum glucose (FSG),hemoglobin and glycated hemoglobin A1c(Hb A1c).RESULTS:The results of the study showed that there were significant differences between patients and controlsin relation to the following parameters :- Serum ferritin , FSG , Hb A1c , total cholesterol , TG and LDL were significantly higher inpatients with type II diabetes mellitus and have metabolic syndrome as compared to the controlgroup. However HDL was Significantly lower in HDL when compared with control group.- There were no significant differences in hemoglobin levels in comparison to the control group.The correlation between serum ferritin levels and the other parameters of the patients sample wereas follows:- A significant positive association with systolic blood pressure (SBP)(r= 0.260) (p= 0.044),withdiastolic blood pressure (DBP)(r= 0.382)(p= 0.0025),with waist circumference(WC) (r= 0.269)(p= 0.037) , with body mass index(BMI) (r=0.289)(p=0.023),with fasting serum glucose(r = 0.27)(p = 0.035), with Hb A1c (r= 0.264) (p= 0.041),with total cholesterol TC)(r= 0.268)(p= 0.038), with triglyceride (TG)(r= 0.279)(p= 0.030), with LDL (r= 0.022)(p= 0.045) But noassociation with HDL (r= 0.184)(p= 0.153).CONCLUSION:The study showed that serum ferritin level could be used as a screening tool for hypertension,diabetes mellitus , atherosclerosis ,cardiovascular diseases and metabolic syndrome.