Investigation the potential role of some medicinal plants extracts in regulating serum lipid profile in female albino rats
Abstract
Strong evidence showed that many medicinal plants have the potential to reducehyperlipidemia disease. The aim of this study was to determine the hypolipidemicactivity of aqueous extracts of Fucus vesiculosus, Coleus forskohlii, Curcuma longaL., Rosmarinus officinalis L., Camellia sinensis L. and Melissa officinalis L. onlipid profile in serum taken from the blood of rats. Fifty-seven female albino ratswere divided into 19 groups, each with three rats, that were treated orally with anaqueous plant extract in three different doses, except the control group which wastreated with normal saline only. The chemical compositions of these extracts wereanalyzed using High Performance Liquid Chromatography (HPLC).The resultsshowed that the dose of 5 mg/kg ofCurcuma longa was the powerful extract whichreduced levels of cholesterol (CHO) and low-density lipoprotein (LDL) in serumrats' blood by 31 and 55%, respectively, compared with the control treatment.While, the effective extract to reduce triglycerides (TG) level was that ofFucusvesiculosus(50mg/kg) which reduced TG by 38% compared with the control. Also,Melissa officinalis(50 mg/kg ) extract reduced 30% of very low-density lipoprotein(VLDL) level as compared to the control treatment. In addition, Coleusforskohlii(100 mg/kg) extract increased high-density lipoprotein (HDL) level by115% after being orally given to rats for four weeks. The results of the studyindicated significant differences among the concentrationsof the secondarycompoundswithin their extracts, which maybe responsible for the observedvariations of hypolipidemic activity for each extract. Based on these results, furtherinvestigation should target understanding the mechanismsby which these plants canbe used as food additives and as dietary supplement.
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