Preterm Premature Rupture of Membranes and the Value of Serum Ferritin during Pregnancy


BACKGROUND:Preterm premature rupture of membranes occurring from 24-37 weeks gestation. Ferritin is an acutephase reactant as it increases during inflammation that inflammation can predispose to pretermpremature rupture of membranes during pregnancy.OBJECTIVE:To investigate the value of serum ferritin as a marker for preterm premature rupture of membrane.PATIENTS AND METHODS:The study includes 150 pregnant women attending the department of Obstetrics and Gynecologywith a gestational age ranging from 28+0 – 36+6 weeks. 50 of them presented with Preterm prematurerupture of membrane (group A), 50 women were presented with spontaneous preterm labor (groupB), and the other 50 were without any complaint (group C). Venous blood samples of five ml werecollected on admission for measurement of serum ferritin level by enzyme-linked immunosorbentassay.RESULTS:No statistically significant differences between study groups regarding age, parity, gestational ageand hemoglobin level (P ≥ 0.05). The mean of serum ferritin was significantly higher amongpregnant women presented with Preterm premature rupture of the membranes than those presentedwith spontaneous preterm labor and healthy women (45.07 versus 26.22 and 22.83 ng/mlrespectively) (P= 0.001). By receiver operating characteristic curve analysis, the cut point of serumferritin value was 38.6 ng/ml.CONCLUSION:Measurement of serum ferritin level is a simple rapid and accurate test. It can be applied as a markerfor preterm premature rupture of membrane.