Correlation Between Chlamydia pneumoniae Infection and Lipid Profile in Patients with Cardiovascular Diseases

Abstract

Cardiovascular disease (CVD) is a class of diseases that involve the bloodvessels or heart. Chlamydia pneumoniae has been considered as the mostreasonable; also, it is able to increase and persevere inside vascular cells and tomake the chronic inflammation in atherosclerosis. In this study, blood samples weresubjected for molecular detection of Chlamydia pneumoniae by using conventionalpolymerase chain reaction (PCR) depending on 16S rRNA. Seventy patients whosuffer from cardiovascular diseases (angina, myocardial infarction andatherosclerosis) aged between 33-86 years have been investigated and compared totwenty of apparently healthy individuals were studied as a control group. Twenty-sixsamples (37.14) % revealed positive results for Chlamydia pneumoniae by PCRtechnique in blood samples of patients group, while all control samples werenegative. No significant relationship was found among HDL,LDL, cholesterol, butthe significant differences in the levels of triglyceride, VLDL between Chlamydiapneumoniae positive and negative within the patients' group were significant(P<0.05).The result of this study revealed that there was elevation of cholesterol andtriglycerides level in patients their ages less than 50 years compared with other agegroups although there was no significant relationship between HDL VLDL,LDLand age ; but generally certain patients with more than 60 years have the highestlevel of HDL VLDL, LDL.