Effect of Annona Muricata Extracts on Some Biochemical Parameters in Rats Exposed to Induced Liver Tumor

Abstract

This research included a study of some biochemical variables of Wister male rats with Induced liver cancer and a study of the effect of extracts of three parts of Annona muricata, including seeds, core, and leaves. The animals were divided into eight groups each group had six rats I: Control group, II treated with Thioacetamide TAA, III treated with Core extract, IV treated with Seed extract, V treated with Leave extract, VI treated with TAA with core extract, VII treated with TAA and Seed extract and, VIII TAA with leave extract. In this study, the measurement kit was used to measure, also Manual methods used to estimate Glutathione, Malondialdehyde, and Paraoxonase. The results showed a P≤0.05 increase in the tumor-induced rats of Malondialdehyde, Alkaline phosphatase, Total bilirubin, Aspartate transaminase, Alanine-transaminase, and Alpha-fetoprotein compared to the control group, while there was a significant decrease in rats which treated with TAA of Total protein, Glutathione, and Paraoxonase compared to the control group. The results showed a significant decrease in the levels in tumor-affected animals and treated with seed extract for each Malondialdehyde, Alkaline phosphatase, Total bilirubin, Aspartate transaminase, Alanine transaminase, and Alpha-fetoprotein compared to the group of rats affected and treated with the core extract, and leaves, The results also showed a significant increase in the affected rats which treated with seeds extract for the level of Total protein, Glutathione, and Paraoxonase compared to the group treated with Core, leaves, this has been demonstrated by the histological sections of the liver.