Microneedle Array Patches: Characterization and in -vitro Evaluation Zainab A. Sadeq*,1

Abstract

Patches in transdermal drug delivery system (TDDS) have been used to overcome the hypodermic needles drawback, However, these patches also have absorption limitation for hydrophilic drugs and macromolecule like peptides and DNA. Therefore, micronized projections which have the ability for skin penetration named as microneedles were developed. Microneedle array patches can penetrate the stratum corenum to form condutis in the epidermis for drug delivery, avoiding nerve fibers and blood vessels contact to minimize pain sensation and bleeding. There are types of microneedles such as solid, coated, hallow, dissolving and hydrogel microneedles with different methods of microfabrication.