The Value of (Chlorzoxazone 250 mg + Paracetamol 300 mg) in Relieving Postoperative Trismus and Pain after Surgical Removal of Impacted Lower Wisdom Teeth (Clinical Study)

Abstract

Background Reduction of postoperative drawbacks related to extraction of lower wisdomteeth is an important goal in oral surgery. Chlorzoxazone, a centrally acting musclerelaxant could be used following surgical removal of lower wisdom teeth, to replace other alternative medications such as steroids, non-steroidal anti-inflammatory drugs, and diazepam particularly when the access to these medications is limited or contraindicated.Objectives This study aims to evaluate a combined therapy (Chlorzoxazone 250 mg + Paracetamol 300 mg), in relieving postoperative trismus and pain after surgical removal of lower wisdom teeth compared with paracetamol 500 mg.Materials and Methods: Thirty healthy patients participated in this prospective clinicalstudy. They were divided into two groups; the test group received the combined therapy (Chlorzoxazone 250 mg + Paracetamol 300 mg) and antibiotic while the control group received just paracetamol 500 mg and antibiotics as postoperative medications. Postoperatively, one independent investigator performed clinical examinations.Results: the combined therapy (Chlorzoxazone 250 mg + Paracetamol 300 mg) presented a good postoperative effect to relieve the trismus related to the operationConclusions could justify the use of this combination therapy as an alternative to steroidal and non-steroidal anti-inflammatory agents particularly when these medications are contraindicated in certain medically compromised patients.