Abstract

Chalcone was prepared by claisen- schmidt condensation between reaction equivalent moles from 4-amino acetophenone with thiophen -2-carboxaldehyde in presence sodium hydroxide as base, the mechanism was involved the abstraction α Proton by base from the α-carbon of the ketone to form carbanion, which attacks carbonyl of aldehyde contains no α-hydrogens to produce α-β-unsaturated ketone, Chalcone derivative used to synthesize pyrazoline derivatives by condensation with 2,4-dinitro phenyl hydrazine. The newly synthesized compounds were determined using spectroscopic methods such as FTIR, Mass spectra, 1H-NMR.

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The article was added to IASJ on 2021-11-26

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