Urinary RBC Count As a Guide to Follow The Activity of Lupus Nephritis

Abstract

Some patients with systemic lupus erythematosus may show hematuria and proteinuria due to renal involvement regardless of the underlying renal histopatholgical lesion. The prognosis and the treatment depend on type and activity of underlying renal lesion. Usually the active lesion shows response to treatment in contrast to chronic lesion which does not. .Renal biopsy seems to be essential procedure in the initial evaluation of renal lesion but not as repeated procedure to follow the lesion. In this study the relation between the activity of renal lesion and its clinical evidence studied in 30 patients with SLE. Renal lesions classified according to WHO classification of lupus nephritis. Hematuria was more common in classes iii and iv both of them show increasing activity score and hematuria show striking correlation with histological activity(r = 0.71). Proteinuria was the most common finding and had a significant association with chronicity score .Serum creatinine had a weak association with both activity and chronicity score .These results show that urinary RBC could be used as a guide to monitor disease activity and response to treatment in stead of serial renal biopsy.