The pattern of spirometric abnormalities in patient with ischemic heart failure in Tikreet

Abstract

Chronic heart failure (HF) is associated with mild to moderate changes in pulmonary function, including restrictive and obstructive changes as well as a reduction in lung diffusing capacity. Although heart failure altered lung function & the causes remains unclear, they have been attributed to respiratory muscle weakness, pulmonary hypertension, changes in lung fluid balance and chronic neurohermonal changes.
The aim of the study is to determine the patterns of spirometric abnormalities in patient with ischemic heart failure. One hundred & twenty subjects participate in this study, 80 patients with ischemic heart failure (53 men & 27 women) & 40 healthy subjects as control (20 men & 20 women). The study extended from the 1st of October 2010 to the 1st of May 2011. For all patients, body weight, height and body mass index were measured. Full medical histories including detailed drug history were obtained. Also, a blood samples were taken to determine the serum uric acid concentration. Patients with clear history of bronchial asthma will be excluded, as well as patients with body mass index more than 40. Spirometric measurements were done for all subjects (patients & controls) by using computerized spirometer of BTL-08LT type provided by BTL Company UK. Patients with congestive heart failure diagnosed by physical examination, ECG, & confirmed by echocardiography. Blood pressure & pulse rate were also measured for all subjects. There are no significant differences regarding age, body weight & height between patients & control healthy subjects in both sexes. There is a significant difference regarding heart rate between patients with ischemic heart failure (IHF), as compare with heart rate of control healthy men & women (P،ـ 0.01). Also, there is significant difference regarding % of FVC from normal between patients with ischemic heart failure (IHF), as compare with control men & women. Moreover, there is a highly significant difference regarding the % of FEV1 from normal value, between patients with IHF, as compare with healthy control men & women. The differences in mean of heart rate, FVC, FEV1 & serum uric acid were significant between male patients & control men (P ،ـ 0.01). The same findings were true for women.