Comparative spectrophoto metric determination of h rip rotidinehydrochloride drug (TPH) using oxidizing agents Potassiumpermanganate & Potassium dichromate

Abstract

This research deals with spectrophotometric method for determination of Triprolidine
Hydrochloride drug (TPH) using two different oxidizing agents; Potassium permanganate
and Fotassium dichromate.The analytical results obtained are as follow:l- The alkaline
media (trlaOH): Potassium permanganate gives green solution which gives spectrum with
amaximum absorption at 6l2nm its found that optimum sonc. for alkaline solution is 1.2X10-
'M and lX10-3M for Potassium permanganate within 10 minutes oxidizing time. The
statistical and other analytical results for drug concentration range (1-12) ppm are as follows:
Correlation coefficient r = 0.9989 , molar absorption coefficient 26993 L/mol.cm and
sandel's sensitivity is 0.0122pg1r*t at Ln,u* =61inm. This method is applied for the
determination of TPH in pharmaceutical preparations with percentage recovery not less than
96.22 %. Z-The acidic media (HCl): Potassium dichromate gives yellow solution with
amaximum absorption at 350 nm the optimum conc .for acidic solution is 1X10'2 M and
l.5Xl0-M for Potassium dichromate duringlS minutes oxidizing time. The statistical and
other analytical results for drug concentration range (1-12) ppm are as follows: Correlation
coefficient r : 0.9969, molar absoqption coefficient 38559.5 L/mol.cm and sandel's
sensitivity is 0.0086p g1" ' at 1.n,'* =350nm This method is applied for the determination of
TPH in pharmaceutical preparations with percentage recovery not less than 94"66%.