Formulation and Stability Studies of Chloramphenicol asOphthalmic Eye Drop

Abstract

The chloramphenicol is D+threo (-) 2,2 dichloro-N-'B-hydroxy -o( hydroxyl methyl)-pnitrophenyl
acetamide , a bacterioststic and highly effective antibacterial against $ (+)
and gr (-) ocular pathogenic bacteria causing conjunctivitis or corneal ulcers. The
ophthalmic preparations of chloramphenicol'are produced in different formulation due to
its lower stability Therefore , the present study introduce the know-how for the
, production of cholramphenicol sterile ophthalmic solution. The ophthaimic preparations
of chioramphenicol 0.4o/, are not produced in Syria as well as the actice agent . Therefore
, the prepared report produces the know - how for the production and study the stability
fbr sterile solution. chloramphenicol for ophthalmic solution is a sterile , dry mixture with
borax buffer .The active ingredient is chloramphenicol at concentration ( 40mg / m1 )
was prepared under aseptic conditions. The fait yellow color ophthalmic solution , clear ,
sterile, isotonic with 306 mOsm lKg, the pH measured at6.51. This solution did not
cause any eye irritation in rabbits after daily application for four consecutive days .
Finaliy, the stability of the prepared chloramphenicol 0.4% eye drops was studied at 4,
25 , 40 and 50C' for 90 days in giass amber containers and calculated tl-re expiration date
of the preparation on was approximately two years