Spectrophotometric Determination of Paracetamol, Ibuprofen, and Caffeine in Pharmaceutical Preparations by Vierordt's Method and Crammer's Rule for Dissolving the Trinomial Equations


A Simple, Fast, and Economic Spectrophotometric method for the Determination of Par, Ibu, and Caf in their Synthetic and Pharmaceutical Mixtures. The method is a Vierordt's method (Simultaneous Equations) and Crammer's rule for dissolving the trinomial equations. The absorbance at maximum wavelength of these components were measured at 242, 222, and 274 nm respectively. The linearity of all calibration curves was 5-50 µg/ml except the calibration curve of Par at 274 nm was 15-50 µg/ml. The values of R2 were between 0.9973-0.9996. the accuracy and precision of the method were tested, The Rec% values were between 95.20138-104.79505% and RSD% values were between 0.85148-3.08486% within-day and 0.92810-2.88425% with-out day. The method was successfully applied for the determination of mentioned components in their synthetic and pharmaceutical mixtures.