Abstract

Globally, back pain is a problem that costs a lot of money and causes a lot of impairment and disability. Present treatment approaches frequently offer suitable alleviation, but do not tackle the underlying causes. In degenerative disorders, the aim was to restore anatomical function by numerous regenerative cellular methods to alleviate lower back pain. Platelet-rich plasma (PRP) is made up of the large number of autologous platelets that are suspended in a limited plasma volume. Furthermore, PRP is prepared by the use of different modalities and could be administered by injection or applied topically. Whereas the mechanism of action is unknown, in vivo and vitro investigations have revealed cellular and biochemical alterations related to mechanical structure and inflammation. Using patient data and animal models, PRP injection research has revealed insight into chondroprotection, pain relief, and the factors which influence the therapeutic efficiency. PRP injection has lately been recommended in a few types of research as a fairly safe way to treat patients who have degenerative disc disease and failed to find other ways to manage their lower back pain. For the sacroiliac joint discomfort, PRP injections aren’t an approved therapy option, and the evidences for their effectiveness is limited to small RCTs and case report studies. According to limited number of prospective studies, PRP injection might be beneficial in treating pain or functional decline resulting from facet joint arthropathy. For improving the evidence quality and evaluating the safety and efficacy of PRP injections for many prevalent causes of chronic back pain, more research is needed.

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The article was added to IASJ on 2022-05-15

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