A Review of Some Treatments for Oral Mucositis Induced by Using 5-Fluorouracil

Abstract

Oral mucositis (OM) remain the principal complication and costly side effect of cancerchemotherapy. It is creating progressively important contribution to mortality rate as theclinical manifestation ranging from moderate including pain and impairs food and drinkingestion to sever mucosal lesion which developed to life threading due to intense immunesuppression. 5-Fluorouracil (5-FU) is a pyrimidine analogue which considered as a vitaltreatment for diversified shapes of solid tumors for over 40 years. Intravenous (IV) route of 5-Fluorouracil medication treating are commonly used. Experimental studies had demonstratedthat the uracil was necessary for sustaining nucleic acid synthesis required for tumor growth,this led to hypothesis the 5-flurauracil might interfere with nucleic acid synthesis and slowtumor growth. Use of 5-FU drug is one of the most common causes of OM. Our reviewdemonstrates and cooperate the drugs and beside diminish riskiness of chemotherapy 5-FU asa causes of OM in experimental animal.