Comparison of the Effect of Combined Infusion of Ephdrine and Phenylephrine, Ephdrine, or Phenylephrine in Prevention of Post Spinal Hypotension in Cesarean Section

Abstract

BACKGROUND:Hypotension is the most common complication after spinal anesthesia for patients undergoing cesareansection. Prevention and treatment of post-spinal hypotension has been frequently investigated.AIM OF STUDY:Our study aimed to compare the effect of prophylactic infusion of combined ephedrine andphenylephrine, ephedrine, or phenylephrine alone in prevention of maternal hypotension after cesareansection.PATIENTS AND METHODS:90 pregnant women that underwent elective cesarean delivery under spinal anesthesia were included anddivided into: group A received an infusion of combined ephedrine and phenylephrine; group B receivedephedrine infusion, and group C received phenylephrine infusion. Maternal parameters were recorded.RESULTS:There was an insignificant difference in demographic data among the groups. The maternal MAP showsno statistically significant difference, but the combined group shows less hypotensive episodes and lessmaternal side effects.CONCLUSION:Prophylactic infusion of ephedrine and phenylephrine combination can effectively decrease spinalanaesthesia related hypotension without any significant side effect.