EVALUATION THE SEDATIVE AND ANALGESIC EFFECT FOR MIXTURE OF TRAMADOL AND METOCLOPRAMIDE IN SHEEP

Abstract

The aim of study was to explore the analgesic and sedative effects of tramadoland metoclopramide co-adminstration in sheep. Injection of tramadol intramuscular at5mg/kg body weight in sheep produced deep sedation, recompense and analgesia incomparison with dose of 2.5mg/kg body weight which produced only mild sedationand failed as analgesic dose. Intramuscular injection of metoclopramide at 20mg/kgbody weight in sheep produced deep sedation, recompense and analgesia incomparisons with dose of 10 mg/kg which produced only sedation and failed asanalgesic dose. Intramuscular injection of metoclopramide at dose20mg/kg ortramadol at 5mg/kg body weight in sheep each alone were produced deep sedation,recumbence and analgesia while metoclopramide at 10mg/kg body weight or tramadola(t2.5mg/kg b. W) produced only mild sedation and each dose felid to producedanalgesia in sheep. Concomitant administration of tramadol at dose2.5mg/kg bodyweight to sheep and metoclopramide at dose 10mg/kg body weight intramuscular assedatives not analgesia dose produced a significant increase in sedation score andproduced deep sedation with recompense as well as good analgesia in comparisonwith control group and group of tramadol or metoclopramide alone.