Serum ferritin level and B12 in a sample of Iraqi re-current aphthous stomatitis patients


Abstract: Background: With a frequency of 50–66%, recurrent aphthous stomatitis (RAS) is one of the most prevalent conditions affecting the oral mucosa. It is unknown how common hematinic deficiencies, such as those in vitamin B12 and ferritin, affect the pre-vention and progression of RAS. Numerous investigations have shown that individuals with RAS have a significant frequency of hematinic deficits. This research compared pa-tients with recurrent aphthous ulcers and healthy controls' serum levels of ferritin and vitamin B12.Subjects, Materials and Methods: Patients who need blood testing to rule out anemia between November 2020 and May 2021 provided the data. The institutional ethics committee gave its approval to the project. 5ml of blood was taken from patients and con-trols in educational labs after they had provided their demographic information (age, gender, occupation, and residance). The serum was then centrifuged at 3000 rpm for 10 minutes before being stored at -20°C until serum ferritin and vitamin B12 levels were de-termined. The information was presented as Mean ± SD. when comparing biochemical parameters between patients and controls using Students unpaired t-test.A p-value of< 0.05 was deemed statistically significant, while a p-value of< 0.001 was deemed highly sta-tistically significant, Results: A total of 30 RAS patients and 30 healthy control with age and gender matches were included. 40% of the patients had low serum ferritin levels and 56.6% of the patients had low serum vitamin B12 levels, according to statistical analysis of the current study. Significant differences were also seen between the two groups' serum levels of ferritin and vitamin B12.Conclusion: Patients with recurrent aphthous stomatitis require serum ferritin and vitamin B12 measurements. In order to stop the recurrence of aphthous ulceration, it's crucial for people with recurrent aphthous ulcers to consume a balanced diet rich in iron and vitamin B12