This research included the study of some chemical properties of Fallujah city sewage and their effect on chemical pollution of Euphrates River–60 Km North west of the capital within Al-Anbar governorate. First part of the work included the field work in which samples Locations were determined by 32 stations, representing the control sample and the second representing the water of river after mixing with last station of sewage of fallujah city. After that, 30 samples were taken from water river, the distance between samples 50m. As for the Laboratory work, it included the analysis of water samples to find out the concentration of soluble salt ,soluble ions, total dissolved solids (TDS), for water ,and deposit content of trace and heavy metals. Results of this study showed that there is space variations in chemical properties of sewage water, this variation reflected in the pH, EC, the value of EC at control station was (2100 µS m-1) while at last station was (1400 µS m-1) while increase of (16%)comparing with control. Total Dissolved solid (TDS) increased, its value of control station was 844 mg L-1 while it was 857 mg L-1 with increase 1.5% comparing with control. Water was classified as moderately saline at control station and become heavy after mixing. Study of chemical properties showed that the control concentration of cations and anions were higher of than the Local and inter natural accepted limits on mixing with sewage. The cations were Na, K, Ca, and Mg at control 28.7,4.3,140.3,55.2 mgL-1 respectively with increase of 10.8,4.7,1.3%and 23.9% respectively comparing with control. Anions (SO4, Cl, HCO3) concentration of control with at were at last station 508.3,152.6,189.1 mg.L-1 respectively with increase 17.6,4.7,13.5 comparing with concentrations of control. Results showed that Fe, Mn, Zn, Cu a control were 0.001, 0.081, 0.002,0.006 mgL-1 respectively, while the concentration at last station were 0.002,0.082,0.003,0.007mg.L-1 with increase of 50,1.2,33.3,14.2% comparing with control. Concentration of heavy metals, Cd, Ni, Pb in control samples were 0.009,0.006,0.007 mg.L-1 respectively while it was at last station 0.010,0.010,0.008 mgL-1 respectively with increase 4.9,56.2,12.5%.