Microalbuminuria among children and adolescents with sickle cell disease

Abstract

BACKGROUND: Sickle cell nephropathy, a heterogeneous group of renal abnormalities resultingfrom complex interactions of sickle cell disease (SCD)‑related factors and non‑SCD phenotypecharacteristics, is associated with an increased risk for morbidity and mortality.AIMS: The aims of this study were to determine the frequency of microalbuminuria (MA) amongpediatric patients with SCD and to determine risk factors for MA among those patients.SUBJECTS AND METHODS: A case–control study was carried out on 120 patients with SCD,2–18 years old, registered at Basrah Center for Hereditary Blood Diseases, and 132 age‑ andsex‑matched healthy children were included as a control group. Investigations included completeblood panel, blood urea, serum creatinine (Cr), urinalysis, and urinary albumin‑to‑Cr ratio (ACR).Logistic regression analysis was used to assess the predictors of MA.RESULTS: Among SCD patients, 39 (32.5%) had MA compared to 6 (4.5%) in the control group.The mean levels of blood urea, serum Cr, and ACR were significantly higher, and the urine‑specificgravity was significantly lower in SCD patients than in the control group (P < 0.05). Logistic regressionanalysis revealed that frequent painful crisis (odds ratio [OR]: 12.146, confidence interval [CI]:3.439–42.952), high serum ferritin (OR: 8.146, CI: 1.802–36.827), deferoxamine therapy (OR: 23.423,CI: 3.961–60.509), and female sex (OR: 4.590, CI: 1.225–17.202) are independent risk factors forMA (P < 0.05).CONCLUSION: The frequency of MA was high among our pediatric SCD patients. Risk factors forMA include female sex, nutritional factors, painful episodes, and iron overload. This is important forplanning for future follow‑up and management of this common disease in our locality.