Optical microscopy for the effect of Piroxicam administration on the placenta of pregnant Mice


The placenta is a vital fetal organ that supplies crucial nutrients and oxygen to the developing fetus, as well as acting as a conduit for carbon dioxide and other fetal waste products to be removed through the maternal circulation. Non-steroidal anti-inflammatory drugs (NSAIDs) are broadly used in pregnancy to treat fever, pain and inflammation. Piroxicam are member of NSAID, used as anti-inflammation drugs. This study we used 20 pregnant (70 days old) albino Swiss mice Mus musculus Balb/c were used. pregnant mice groups were divided into four groups, Therapeutic, overdose1(T1) and overdose2 (T2) and control, each one of them were injected Intra Peritoneum by different doses of Piroxicam (0.0714, 0.1428, 0.71428) mg/kg respectively once daily for 20 days and control group was injected by normal saline .the result was revealed, engorged maternal blood vessels by RBCs, mesenchymal cell degeneration, giant cell vacuolization, Fibroid deposition in maternal blood, chorionic villi atrophy, vacuolization of syncytiotrophoplasts, Necrosis of the embryonic lacunae, Cluster of epithelial mesenchymal cells, Fibroid Odema in blood vessels, thickened walls, desquamated endothelia wall of maternal blood vessels, hyperplasia in syncytiotrophoblast and hypoplasia of syncytiotrophoblast cells . The results observed in this study showed that Piroxicam was harmful on placenta of pregnant mice. This suggests that this drug should be used with care during pregnant period in humans.