Effects of Aqueous and Alcoholic Extraction of Salvia officinalis on Mechanical Activity of Smooth Muscle of Ileal Rabbit


The effect of different dosesof aqueous (boiled) and alcoholic extraction of Salvia officinalison rhythmic spontaneous activity of ileal smooth muscle of rabbit was investigated. The results indicate that meramea has spasmolytic effect on the smooth muscle of ileum of Rabbit. The dose 5, 10, 15, 20 mg/ml of aqueous (boiled) extract causes an inhibition of muscles rhythmic contraction. While the methanolic extraction of salvia officinalis 5, 10, 15, 20 mg/ml causes an increased in the duration of peristalitic movement (contraction and relaxation) of smooth muscle. This study is proved how the aqueous (boiled) extraction inhibit the peristaltic movement while the effect of methanolic extraction is opposite, if increase the duration of contraction and relaxation period, due to the active component (flavonides) of salvia officinalis.