Abstract

One of the key goals in treating illnesses like candidiasis and other infections associated with Candida is the development of novel antifungal drugs manufactured from natural substances. Current treatments for illnesses like candidiasis and other infections associated with Candida have detrimental effects on human health. Thus, discovering novel antifungal medications from natural sources is urgently needed. This study w to was carried out to evaluate the efficiency of a powder extract of Phellinus igniarius against drug-resistant Candida albicans isolates. This plant is widely utilized in Asian countries and has shown promising pharmacological capabilities.The efficacy of Phellinus igniarius compared with ketoconazole alone and combined with it, A systemic candidiasis mouse model was used to assess Phellinus igniarius' efficacy in vitro and in vivo in treating systemic Candida albicans infections when compared to ketoconazole alone and when combined with it. In vitro minimum inhibitory concentrations (MICs) determined. The antifungal efficacy was determined by measuring the zone of inhibition in a well diffusion experiment. The extract showed strong inhibitory efficacy at ratios of 250:0.2, 500:0.2, and 1000:0.2 against Candida albicans resistance. In contrast, a modest synergistic impact was shown at only 125:0.2 and 0.2 ketoconazole ratios. In addition, the minimum inhibition concentration of each antifungal agent was shown to be decreased when combined with a powder extract of Phellinus igniarius, indicating the presence of synergistic interactions. The rate at which the wounds of the different groups of rats injected with candida healed differed significantly from one another. This group was used as the control and received only the vehicle as treatment. Another group was given ketoconazole as the only drug, while the remaining four groups were given Phellinus igniarius in combination with ketoconazole in varied dosages.The ratios of 250 to 0.2, 500 to 0.2, and 1000 to 0.2 provided the greatest synergistic impact. A minuscule synergistic impact was seen at ratios of 125 to 0.2. To manage infections caused by Candida species while minimizing their hazardous side effects, it is possible to adopt a therapy including combinations of powder extract of Phellinus igniarius and traditional antifungal medications.

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The article was added to IASJ on 2023-10-30

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