THE EXPRESSION OF CD74 MOLECULE IN H.PYLORI INFECTED GASTRIC MUCOSAL TISSUE

Abstract

Background: Helicobacter pylori cause gastric inflammation. Recent interest has been focused on the role of CD74 (the class II MHC-associated invariant chain expressed on the surface of gastric epithelial cells) as an adhesion molecules used by H.pylori that may contribute to the proinflammatory immune response seen during infection.Objective: The aim of this study was to detect the CD74 mucosal expression in H.pylori infected patients and compare it with uninfected patients. Patients and Methods: Sixty-four patients’ age mean (34± 1.7) years (14-66 years) who underwent upper gastrointestinal endoscopy because of gastrointestinal complaints, were studied. A number of both invasive and non-invasive diagnostic tests were used for the diagnosis of H. pylori infection, as well as immunohistochemical study of biopsy specimens to detect the CD74 mucosal expression.Results: After the diagnosis of H.pylori infection, patients were grouped as H. pylori positive,(n=47)and H. pylori negative (n=17). According to immunohistochemical study of biopsy specimens, the expression of CD74 was observed in infected subjects, and there was a significant difference in the CD74 expression (p= 0.005) between infected and uninfected patients.Conclusion: According to immunohistochemical study of biopsy specimens an overexpression of CD74 was observed in infected subjectsKeywords: Helicobacter pylori; CD74; gastric epithelial cells; Immunohistochemistry (IHC)