Serum Cortisol in Type 1 Diabetic females


Background: Diabetes mellitus is regarded as one of the commonest metabolic disorder all over the world. It can cause various endocrine disorders by affecting the secretion, metabolism, clearance or bioavailability of hormones. Aim of study: This study is to answer if type1 diabetes changes cortisol level in female diabetic patients who have different degrees of glycemic control. Subjects, Materials and Methods: This study includes (81) female subjects, age ranged from (15 to 37) years. (20) subjects are apparently healthy chosen as control group and (61) patients with type 1 diabetes mellitus were divided into two groups according to their glycemic control : (16) with poor glycemic control (HbA1c>8%) and (45) with acceptable glycemic control (HbA1c<8%) . In this study Cortisol was quantitatively determined in patients and healthy subjects by Enzyme-Linked Immuno sorbent Assay [ELISA] test using commercially available kits. In addition to that, the duration of disease, fasting plasma glucose (FPG) ,Glycated hemoglobin (HbA1c), and body mass index (BMI) were identified in the patients. RESULTS: In poor glycemic control group, Cortisol level (267.89±16.60 ng/ml,p<0.05) was higher than in acceptable glycemic control group (126.84±4.55 ng/ml,p>0.05) and in nondiabetic patients (123±6.13 ng/ml ,p>0.05). CONCLUSIONS In type 1 female diabetic subjects, adrenal activity is enhanced in patients with poorly controlled patients diabetes and the degree of cortisol secretion is related to the glycemic control