Abstract

The present work involves a study of the polarographic behavior of pure Furosemide(lasimex) by direct method in aqueous solution , which gives a two well defined reduction peaks, the main peak at a potential (-0.196) volts and the other small peak at (-0.236) volts in phosphate buffer (pH=3).The calibration of Furosemide was constructed in phosphate buffer (pH=3) the calibration curves in the potential (-0.196) volts were observed in the range of concentration (6.8310-5 - 9.9010-5) M with a correlation coefficient (0.9884), and second in the range of concentration (10.5110-5-12.3410-5) M with a correlation coefficient (0.9919). The calibration curve of Furosemide in the presence of human blood serum was studied in the potential (-0.187) volts and range concentration of current (7.4410-5-15.3810-5) M with a correlation coefficient (0.9971). The calibration curve of Furosemide in presence of urine in the potential (-0.084) volt and range of concentration (7.4210-5-12.3110-5) M with a correlation coefficient (0.9960). The method was successfully applied to the determination of Furosemide in tablets in aqueous solution and in the presence of valium voltammetrically with out interferences.

Keywords

The article was added to IASJ on 2012-05-23

688 Total full text downloads since the date of addition