Abstract

The elucidative diminished of immune function connecting t the Zinc profile is one of themajor highlighted study all over the world. The aim of this study is to evaluated Zn concentrationin serum of cutaneous leishmaniasis patients and efficacy on some immunological parameters.Atotal of 60 patients with cutaneous leishmaniasis (CL) were included in this study during theperiod between February /2009 to July /2009 in the out – patients clinic of the dermatologydepartment of Azadi General Hospital in Kirkuk governorate.In vitro by using flame atomicabsorption spectrophotometer .It was conclude that the mean of serum Zn level in all CL patientswere significant decreased (P< 0.05) , since the mean concentration in patients group were 7.61±0.03 μmol / l, 6.69 ± 0.31 μmol / l , while they were 14.8 ± 0.04 μmol / l, 12.02 ± 0.02 μmol / lin control groups respectively. Analysis of CD4+ and CD8 + T-lymphocyte percentage showsthat the mean of CD4+ and CD8 + percentage in all CL patients were significant decreased (P <0.05) since the mean percentage of CD4+ in patients groups were 36.5 ± 0.098 % , 36.29 ±0.06% and it was 59.95 ± 0.16%, 58.9 ± 0.14% in control groups respectively .While CD8 +presenting in patients groups were 22.37 ± 0.05 %, 22.47 ± 0.04% , while they were 30.95 ±0.12%, 31.15± 0.15 in control groups respectively. The mean ratio of CD4+/ CD8+ wassignificant decreased in male and female patients in comparison with their control groups , sincethe mean of CD4+ / CD8+ in patients groups were 1.63 ± 0.004, 1.62 ± 0.004 , while they were1.94 ± 0.01 and 1.9 ± 0.01 in control groups

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The article was added to IASJ on 2012-05-23

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