Using of Sintering and Microwave Techniques to Control the Release of Trifluoperazine HCl fromWax Matrix

Abstract

The very water soluble drug, trifluoperazine HCl was prepared assustained release carnauba wax matrix tablets using direct compression method.Different amounts of carnauba wax as matrix substance was used to show itseffect on drug release. Also sintering as new technique was used in order toretard the drug release from carnauba wax matrix tablets; the granules beforecompression or the tablets after compression were exposed to 90°C or 120°C for3 or 5 minutes. Microwave is another technique which was used to prolong thedrug release from carnauba wax matrix tablets. The granules before compressionor the tablets after compression were exposed to microwave irradiation at 600watt for 3 or 5 minutes.The results revealed that the release of drug decreased significantly(p<0.05) when the when the amount of carnauba wax was increased. On theother hand, sintering of granules or tablets, exhibited a significant (p< 0.05) drugrelease retardation when the temperature was increased from 90° C to 120° C.Furthermore, non significant differences (p> 0.05) in drug release was shown atdifferent time of sintering for 90°C or 120°C. The microwave irradiationdirectly on tablets had a significant (p< 0.05) retarding effect on drug release,particularly for tablet exposed to 5 minutes since the drug release prolongedfrom 3hr for unmicroaved tablet to 6 hr for microwaved one.