Medico-legal and Serological Study of the Role of C- Reactive Protein and Anticholesterol Auto-antibodies in the Diagnosis of Ischemic Heart Disease

Abstract

ABSTRACT:BACKGROUND:No previous Iraqi study was done on the role of C - reactive protein (CRP) and anticholesterolautoantibodies (ACHA) in the diagnosis of ischemic heart disease (IHD) especially from the medico-legalpoint of view.AIMS OF THE STUDY:To determine the role of CRP and ACHA in the diagnosis of IHD particularly myocardial infarction (MI)with special attention to the medico- legal aspect.METHODS:Forty four lived patients from Al- Kadhimiya hospital and 20 cadavers in medico-legal institute ofBaghdad were included in this study, in addition to 18 apparently healthy persons and 3 cadavers ascontrols. A number of risk factors were studied such as age, sex, smoking, and others. CRP and ACHAdetected and estimated in the sera of the lived and dead patients. Histopathological examination was doneon cardiac tissue specimens taken from the cadavers.RESULTS:Patients with anterior MI have higher CRP values than in patients with other types of MI. ACHA of IgMtype was higher in controls than in lived and patients, while that of IgG was higher in lived patients ascompared with dead patients and controls.CONCLUSION:Elderly males are affected more by MI. CRP is elevated in acute coronary syndrome. ACHA are presentin healthy individuals, but high in CAD.