Controlled Release From Crosslinked Polyacrylic acid As Drug Delivery Theophylline


AbstractIn this search polyacrylic acid (PAA) hydrogels were synthesized by radical polymerization in solution with N,N'-Methylene bis acryl amide (MBA), as crosslinking agents and potassium persulfate (KPS), sodium metabisulfite (SMBS) as type of mixed redox initiators, poly acrylic acid hydrogel structures were prepared by using N,N'-Methylene bis acryl amide (MBA) as crosslinking agent (0.05, 0.1, 0.15, 0.2, 0.25 )g. at temperature 700C for 4 hr. The swelling ratio (Rs) was measured for all the hydrogel structures, in three different media (pH=2), (pH=4) and (pH=7.2), and three different temperatures (37, 45, 50 )0C as function of time. Theophylline was loaded into polymeric matrix during in situ polymerization, The concentration of theophylline released was measured on UV-Vis spectrophotometer. The drug release studies from the theophylline loaded hydrogel was studied in three different media (pH=2 ,4 and 7.2),and three different temperature (37, 45 and 50) 0C as function of time. The results showed that the samples involving the highest release of theophylline were arranged as follows :PAA-MBA0.05 > PAA- MBA0.1 > PAA- MBA0.15 >PAA- MBA0.2>PAA- MBA0.25