Blood Glucose Concentration and Ischemic Heart Failure


SUMMARY:BACKGROUND:Schemic heart failure (IHF) is the most common cause of congestive heart failure. Several studies have revealed that hyperglycemia is an independent risk factor for the progression of IHF in the general population.OBJECTIVE:Is to evaluate the relationship between fasting blood glucose concentration and the development of IHF in patients with CAD.METHODS:This study included 28 patients with IHF, 22 patients with coronary artery disease (CAD) without HF and 22 healthy controls. Fasting plasma glucose, total cholesterol, and low density lipoprotein-cholesterol( LDL- C) were measured in these two groups of patients and controls.RESULTS:The present study revealed that the mean (± SEM) value of fasting plasma glucose in patients with IHF (127 ± 7.64 mg/dl) was significantly higher than that obtained from CAD patients without HF (93.6 ± 3.96 mg/dl, P<0.0001) as well as from healthy controls (80.8 ± 2.52 mg/dl, P<0.0001). The mean values (± SEM) of serum total cholesterol and LDL-Cholesterol did not differ significantly among the three groups of the present study.CONCLUSION:This study showed that serum glucose level may play an important role (partially) in the development and progression of IHF in patients with CAD and normal cardiac contractile function.