Histological Changes in Liver Associated with Administration of Hydroxyurea in Male Albino Mice

Abstract

Hydroxyurea ( HU ) have been used for treatment of a variety of tumors . It becomes standard therapy for chronic myelogenous leukemia , polycythemia and sickle cell disease . Numerous studies have been published about their side effects but less studies has dealt with HU effect in histological structure of liver , therefore these experiments were designed to study the effect of HU on hepatic tissue .We concluded that HU had negative side effect in the liver.