THE EFFECT OF SUBCUTANEOUS ADMINISTRATION OF LEAD ACETATE ON BRAIN TISSUE: A HISTOPATHOLOGIC STUDY

Abstract

peripheral nervous systems causing irreversible changes manifested as a collection of neurological symptoms. The aim of this work is to study the effect of subcutaneous administration of lead acetate on the brain tissue of rabbits by histopathological examination. Material and Methods: Five males rabbits 4-5 weeks in age underwent subcutaneous injection of lead acetate in a dose of 1 mg / animal for 2 days, followed by 2 mg / animal for 6 days. Animals were sacrificed on the 9th day and their brain tissues were subjected to histopathlogic study compared to those of 5 animals used as a control group. Results: Histopathologic changes included endothelial proliferation of small blood vessels, oedema and focal demyelination of the brain tissue leading to a rarified appearance. Conclusion: These findings represent the direct effect of small doses and short exposure to lead on the brain tissue leading to irreversible damage